Drug intelligence / Profile preview

alectinib + atezolizumab + entrectinib + divarasib

Development stage
Unknown
Lead developer
Roche
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous, Oral
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Overview

**Alectinib + atezolizumab + entrectinib + divarasib** denotes a four-agent anticancer treatment concept comprising three targeted small-molecule kinase inhibitors and the anti-PD-L1 monoclonal antibody atezolizumab. Alectinib inhibits ALK and RET; entrectinib inhibits TRKA, TRKB, TRKC, ROS1, and ALK; divarasib is an irreversible, mutation-selective KRAS G12C inhibitor; and atezolizumab blocks PD-L1-mediated immune checkpoint signaling. No public source was identified that establishes this exact four-drug combination as a defined co-formulated product or a specific clinical regimen. Roche platform trials have listed these medicines as separate biomarker-directed interventions or cohort options rather than as one simultaneous four-drug regimen.

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Targets

ALK (Anaplastic lymphoma kinase receptor tyrosine kinase)CD274 (Programmed cell death protein 1 ligand 1)RET (Rearranged during transfection receptor tyrosine kinase)KRASG12C (Kirsten rat sarcoma viral oncogene homolog G12C)NTRK1 (Tropomyosin-related receptor kinase A)NTRK2 (Tropomyosin-related kinase receptor type B)NTRK3 (Tropomyosin receptor kinase C)ROS1 (Proto-oncogene tyrosine-protein kinase ROS)

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