alfacalcidol + calcium

Alfacalcidol + Calcium is a combination pharmaceutical product marketed by Onyx Pharmaceuticals. Alfacalcidol is a synthetic analog of vitamin D that acts as a prodrug, undergoing rapid conversion in the liver to calcitriol (1,25-dihydroxyvitamin D3), the active metabolite of vitamin D. It regulates calcium and phosphate metabolism by increasing intestinal absorption and renal reabsorption. Calcium is included as a mineral supplement to provide the necessary substrate for bone mineralization. This combination is primarily used for the management of conditions associated with vitamin D deficiency or impaired metabolism, such as osteoporosis, renal osteodystrophy, and hypocalcemia. It is particularly beneficial for patients with renal impairment, as alfacalcidol does not require renal hydroxylation for activation.

Other names

1-alpha-hydroxyvitamin D3 + calcium