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alfacalcidol + calcium
- Development stage
- Phase 3
- Lead developer
- LEO Pharma
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Alfacalcidol + Calcium is a combination pharmaceutical product marketed by Onyx Pharmaceuticals. Alfacalcidol is a synthetic analog of vitamin D that acts as a prodrug, undergoing rapid conversion in the liver to calcitriol (1,25-dihydroxyvitamin D3), the active metabolite of vitamin D. It regulates calcium and phosphate metabolism by increasing intestinal absorption and renal reabsorption. Calcium is included as a mineral supplement to provide the necessary substrate for bone mineralization. This combination is primarily used for the management of conditions associated with vitamin D deficiency or impaired metabolism, such as osteoporosis, renal osteodystrophy, and hypocalcemia. It is particularly beneficial for patients with renal impairment, as alfacalcidol does not require renal hydroxylation for activation.
- Other names
- 1-alpha-hydroxyvitamin D3 + calcium
02
Targets
VDR (Vitamin D receptor)
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