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ALFQ (U.S. Military HIV Research Program)
- Development stage
- Unknown
- Lead developer
- U.S. Military HIV Research Program
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
ALFQ (Army Liposome Formulation with QS-21) is a potent liposomal adjuvant system developed by the U.S. Military HIV Research Program (MHRP) at the Walter Reed Army Institute of Research (WRAIR). It is composed of synthetic monophosphoryl lipid A (3D-PHAD), cholesterol, phospholipids (DMPC and DMPG), and the saponin QS-21. ALFQ is designed to enhance both humoral and cellular immune responses to co-administered antigens. It has been evaluated in clinical trials for various infectious diseases, including HIV-1 and malaria, often in combination with protein subunit vaccines like A244d11gp120. The formulation is a more potent version of the earlier ALF (Army Liposome Formulation) and ALFA (ALF with Aluminum hydroxide) adjuvants.
- Other names
- Army Liposome Formulation with QS-21
02
Targets
TLR4 (Toll-like receptor 4)Membrane cholesterol and lipid rafts
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