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all-trans retinoic acid + mifepristone + tamoxifen + cannabidiol
- Development stage
- Phase 3
- Lead developer
- Mahmoud Ramadan mohamed Elkazzaz
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This investigational quadrate combination therapy, developed by Mahmoud Ramadan Mohamed Elkazzaz, is being evaluated for the treatment of early breast cancer. The regimen consists of all-trans retinoic acid (ATRA), mifepristone (an antiprogesterone), tamoxifen (a selective estrogen receptor modulator), and cannabidiol (acting as a selective CYP26 inhibitor). The therapeutic rationale is based on preventing the induction of therapy-resistant cytokeratin 5 (CK5)-expressing cancer stem cells, which are often expanded by progesterone or standard hormonal treatments. In this protocol, mifepristone counteracts the progesterone-mediated induction of CK5+ cells, while cannabidiol is included to inhibit CYP26 enzymes, thereby preventing the degradation of retinoic acid and potentially enhancing its anti-tumor activity. Additionally, cannabidiol acts as an atypical inhibitor of CYP2D6 to modulate the metabolic profile of the combination.
- Other names
- Quadrate combination therapyMifepristone + Tamoxifen + Retinoic acid + CannabidiolATRA + Mifepristone + Tamoxifen + Cannabidiol
02
Targets
CYP26A1 (Cytochrome P450 26A1)CYP2D6 (Cytochrome P450 2D6)ESR1 (ERα)ESR2 (ERβ)GR (Glucocorticoid receptor)PR (Progesterone receptor)RARA (Retinoic acid receptor alpha)RARB (Retinoic acid receptor beta)RARG (Retinoic acid receptor gamma)RAR (Retinoic acid receptor)
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