allisartan isoproxil + amlodipine

Allisartan isoproxil + amlodipine is a fixed-dose combination tablet containing two antihypertensive agents: allisartan isoproxil (an angiotensin II type 1 receptor blocker, ARB) and amlodipine (a calcium channel blocker, CCB). This combination is indicated for the treatment of essential hypertension in adults whose blood pressure is not adequately controlled by either agent alone. Allisartan isoproxil acts as a prodrug that converts to its active metabolite EXP3174 after oral administration; this metabolite selectively blocks the angiotensin II type 1 receptor (AT1R), reducing vascular resistance and blood pressure. Amlodipine inhibits L-type calcium channels in vascular smooth muscle, leading to vasodilation and further lowering of blood pressure. The product was developed as an original domestic compound preparation in China by Shenzhen Salubris Pharmaceuticals for improved efficacy in patients with poor response to monotherapy[1][5][6][8].

Brand names

FoLitan复立坦Fu Li Tan

Other names

allisartan and amlodipine tabletsallisartan isoproxil and amlodipine besylate tablets