Drug intelligence / Profile preview

allisartan medoxomil + amlodipine

Development stage
Unknown
Lead developer
Daiichi Sankyo
Modality
Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
Administration
Oral
01

Overview

Allisartan medoxomil + amlodipine is a fixed-dose combination antihypertensive medication containing two active ingredients: - **Allisartan medoxomil** is an angiotensin II receptor blocker (ARB) that works by selectively blocking the binding of angiotensin II to the AT1 receptor in vascular smooth muscle, leading to vasodilation and reduced blood pressure. - **Amlodipine** is a dihydropyridine calcium channel blocker (CCB) that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle, resulting in relaxation of blood vessels and further lowering of blood pressure. This combination targets two different mechanisms involved in hypertension, providing additive or synergistic effects for better control of high blood pressure. The primary indication for this drug is the treatment of hypertension (high blood pressure).

Other names
allisartan medoxomil and amlodipineallisartan + amlodipine
02

Targets

CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)AGTR1 (Angiotensin II Type-1 receptor)

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