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allogeneic adipose-derived mesenchymal stem cells (AIAT)
- Development stage
- Unknown
- Lead developer
- Red Andaluza de Terapias Avanzadas
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Allogeneic adipose-derived mesenchymal stem cells (AIAT) is an investigational cell therapy developed by the Andalusian Initiative for Advanced Therapies (Fundación Pública Andaluza Progreso y Salud). The therapy consists of expanded mesenchymal stem cells (MSCs) harvested from the adipose tissue of healthy donors. It is specifically being evaluated for the treatment of HIV-infected individuals who exhibit a discordant immunological response—a condition where patients maintain suppressed viral loads under antiretroviral therapy (ART) but fail to achieve adequate CD4+ T-cell recovery. The mechanism of action leverages the immunomodulatory and anti-inflammatory properties of MSCs, which are intended to reduce chronic immune activation and systemic inflammation, thereby facilitating immune reconstitution. The cells are administered via intravenous infusion in multiple doses.
- Other names
- allogeneic adipose tissue-derived mesenchymal stem cellsallogeneic adult mesenchymal stem cells from adipose tissue expandedMSCs-AIATallogeneic adipose-derived mesenchymal stem cells-Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud-HIV infection
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