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allogeneic umbilical cord-derived mesenchymal stromal cells (Institute of Oncology Ljubljana)
- Development stage
- Unknown
- Lead developer
- Institute of Oncology Ljubljana
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intraglandular Injection
01
Overview
This investigational cell therapy, developed by the Institute of Oncology Ljubljana, utilizes allogeneic mesenchymal stromal cells (MSCs) derived from umbilical cord tissue for the treatment of radiation-induced xerostomia. Targeted at patients with head and neck cancer who have suffered salivary gland damage following radiotherapy, the MSCs are administered via ultrasound-guided injection directly into the parotid or submandibular glands. The therapy aims to restore salivary function by leveraging the MSCs' innate immunomodulatory, anti-inflammatory, and regenerative properties to repair damaged glandular tissue. It is currently being evaluated in a Phase I pilot clinical trial to determine safety and preliminary efficacy in patients who have been disease-free for at least two years post-treatment.
- Other names
- Allogeneic Mesenchymal Stromal CellsAllogeneic Mesenchymal Stromal Stem CellsAllogeneic MSCs
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