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almonertinib + SHR-1701
- Development stage
- Phase 2
- Lead developer
- Hengrui Therapeutics
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Almonertinib is a third-generation small molecule EGFR tyrosine kinase inhibitor that targets both EGFR-sensitizing and T790M resistance mutations, primarily developed for the treatment of advanced or metastatic EGFR-mutated non-small cell lung cancer (NSCLC)[8]. SHR-1701, also known as retlirafusp alfa, is a bifunctional recombinant fusion protein composed of an anti-PD-L1 monoclonal antibody fused to the extracellular domain of TGF-beta receptor II. This design enables dual inhibition of PD-L1 and TGF-beta signaling pathways, aiming to enhance antitumor immune responses[5][2][3]. The combination of almonertinib with SHR-1701 is being investigated in clinical trials for relapsed or advanced malignancies, including NSCLC and other solid tumors[1][4].
- Brand names
- Ameile
- Other names
- aumolertinib (for almonertinib)retlirafusp alfa (for SHR-1701)
02
Targets
EGFR (Epidermal growth factor receptor)CD274 (Programmed cell death protein 1 ligand 1)TGFBR2 (TGF-β receptor type 2)
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