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aloe vera + dutasteride
- Development stage
- Unknown
- Lead developer
- Diponegoro University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This combination therapy, developed by Universitas Diponegoro, pairs the dual 5-alpha-reductase inhibitor dutasteride with Aloe Vera extract for the treatment of benign prostatic hyperplasia (BPH). Dutasteride works by inhibiting both Type I and Type II isoforms of the 5-alpha-reductase enzyme, which prevents the conversion of testosterone into dihydrotestosterone (DHT), the primary androgen driving prostate growth. The addition of Aloe Vera extract is intended to target angiogenesis pathways, specifically by reducing vascular endothelial growth factor (VEGF) levels, potentially offering a synergistic effect on prostate volume reduction and improvement in urinary flow (uroflowmetry) compared to standard monotherapy.
- Other names
- Aloe Vera Extract + Dutasteride
02
Targets
AR (Adrenergic receptors)SRD5A2 (Steroid 5-alpha-reductase type II)SRD5A1 (Steroid 5-alpha-reductase type 1)
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