Drug intelligence / Profile preview

alpelisib + trastuzumab

Development stage: Unknown
Lead developer: Novartis
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration: Oral, Intravenous

Overview

A combination therapy consisting of alpelisib, an alpha-specific PI3K inhibitor, and trastuzumab, a HER2-targeted monoclonal antibody. This combination targets both the PI3K pathway and HER2 receptor to overcome resistance mechanisms in breast cancer, particularly in patients with PIK3CA mutations. The combination has shown synergistic effects in preclinical studies and is being evaluated in clinical trials for HER2-positive PIK3CA-mutated advanced breast cancer.

Targets

PIK3CA (Phosphoinositide 3-kinase alpha)ERBB2 (Erb-b2 receptor tyrosine kinase 2)

Beyond the preview

Go deeper on alpelisib + trastuzumab.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on alpelisib + trastuzumab.

Explore the full profile