Drug intelligence / Profile preview

alpha-amyrenone + beta-amyrenone

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Alpha-amyrenone + beta-amyrenone (α,β-amyrenone) is a natural mixture of two pentacyclic triterpenes isolated from plants such as *Aleurites moluccana*. It functions as a small molecule therapeutic candidate with dual anti-inflammatory and metabolic regulatory properties. Preclinical studies indicate that the mixture reduces neutrophil migration and mechanical hypersensitivity in models of inflammation and arthritis. Furthermore, it demonstrates selective inhibition of alpha-glucosidase and pancreatic lipase, suggesting potential applications in the management of type 2 diabetes, obesity, and metabolic syndrome. Currently, it remains a research-stage compound without a commercial pharmaceutical developer.

Other names
alpha,beta-amyrenoneα,β-amyrenonealpha-amyrenone and beta-amyrenone mixture
02

Targets

MGLL (Monoacylglycerol lipase)

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