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alpha-interferon + abidol + ribavirin + Buzhong Yiqi plus and minus formula + Huhuang Detoxicity Paste + Baimu Qingre Jiedu Paste + glucose

Development stage
Preclinical
Modality
Cytokines & Interferons → Recombinant Proteins and Enzymes, Small Molecules
Administration
Inhalation (alpha-interferon)[9], Oral (abidol/arbidol)[9], Intravenous (ribavirin)[9], Oral/topical/other Routes Possible For Tcm Pastes/formulas[6][9], Intravenous/oral For Glucose[9]
01

Overview

This is a multi-component combination therapy consisting of both pharmaceutical antivirals and traditional Chinese medicine (TCM) formulas, as well as glucose. The pharmaceutical components include alpha-interferon (a cytokine with antiviral and immunomodulatory effects), abidol (also known as arbidol, an antiviral that inhibits viral entry), and ribavirin (a nucleoside analog with broad-spectrum antiviral activity). The TCM components—Buzhong Yiqi plus and minus formula, Huhuang Detoxicity Paste, and Baimu Qingre Jiedu Paste—are herbal preparations traditionally used to support immune function, clear heat/toxins, or treat infections according to TCM theory. Glucose serves as a supportive agent for energy or intravenous administration. This combination has been studied in the context of integrated Chinese-Western medicine approaches for acute viral infections such as COVID-19[9]. Mechanistically, the pharmaceuticals target viral replication or modulate host immunity; the herbal pastes are believed to have immunomodulatory or anti-inflammatory effects based on traditional use.

02

Targets

HA (Hemagglutinin)IFNAR (Immune system modulation via type I interferon receptor)RdRp (Coronavirus RNA-dependent RNA polymerase)

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