Drug intelligence / Profile preview

alpha-interferon + etoposide

Development stage: Unknown
Lead developer: University of Texas MD Anderson Cancer Center
Modality: Cytokines & Interferons → Recombinant Proteins and Enzymes, Small Molecules
Administration: Intravenous, Subcutaneous, Intramuscular, Oral

Overview

Alpha-interferon + etoposide is a combination regimen of two antineoplastic agents used experimentally in oncology. Alpha-interferon (interferon alfa) is an immunomodulatory cytokine that binds to the interferon alpha/beta receptor 1, activating immune responses and exerting antiproliferative effects. Etoposide is a small molecule chemotherapeutic agent that inhibits DNA topoisomerase II, leading to DNA strand breaks and inhibition of cell division. The combination has been studied in clinical trials for various cancers, including colorectal carcinoma and osteosarcoma, with mixed results regarding efficacy. The rationale for combining these drugs includes potential synergistic cytotoxicity against tumor cells[1][2][3].

Other names: interferon-alpha + etoposideIFN-alpha + etoposide

Targets

IFNAR1 (Interferon alpha/beta receptor 1)TOP2A (DNA topoisomerase II)

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