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Drug intelligence / Profile preview
alpha-lipoic acid + benfotiamine + folic acid + inositol + methylcobalamin + pregabalin + pyridoxine
- Development stage
- Unknown
- Lead developer
- Sanrey Therapeutics
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Pregarey Forte is a fixed-dose combination oral tablet developed by Sanrey Therapeutics for the management of neuropathic pain, particularly diabetic neuropathy and peripheral neuropathy. It combines the gabapentinoid anticonvulsant pregabalin with a comprehensive blend of neurotropic vitamins and antioxidants, including methylcobalamin (vitamin B12), alpha-lipoic acid, benfotiamine (vitamin B1 derivative), inositol, pyridoxine (vitamin B6), and folic acid (vitamin B9). Pregabalin acts by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters and calming overactive nerves. The vitamin and antioxidant components work synergistically to support myelin sheath regeneration, promote nerve repair, reduce oxidative stress, and improve overall nerve conduction and metabolic function.
- Brand names
- Dugalin Forte 75Pregamec FortePregarey Forte
- Other names
- alpha-lipoic acid + benfotiamine + folic acid + inositol + methylcobalamin + pregabalin + pyridoxine hydrochloridebenfotiamine + folic acid + inositol + methylcobalamin + pregabalin + pyridoxine + alpha-lipoic acid
02
Targets
CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)CACNA2D2 (Voltage-gated calcium channel subunit alpha-2/delta-2)MTR (Methionine synthase)
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