Drug intelligence / Profile preview

alpha-lipoic acid + high molecular weight sodium hyaluronate

Development stage
Unknown
Modality
Small Molecules, Hydrogel Systems → Drug Delivery Systems, Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Ophthalmic, Topical
01

Overview

Alpha-lipoic acid combined with high molecular weight sodium hyaluronate is formulated as a preservative-free ophthalmic emulsion primarily used to manage oxidative stress and inflammation on the ocular surface, particularly in patients with dry eye disease. Alpha-lipoic acid acts as an antioxidant that can reduce oxidative damage and inflammation, while high molecular weight sodium hyaluronate provides lubrication, hydration, anti-inflammatory effects, and supports tissue repair. The combination shows synergistic benefits improving quality of life scores and markers of oxidative stress and inflammation in dry eye disease patients. This formulation leverages alpha-lipoic acid’s antioxidant properties alongside the viscoelastic and anti-inflammatory actions of high molecular weight sodium hyaluronate to enhance ocular surface health[1][4][6].

02

Targets

ICAM1 (Intercellular Adhesion Molecule 1)RHAMM (Hyaluronan-mediated motility receptor)LYVE1 (Lymphatic vessel endothelial hyaluronic acid receptor 1)STAB2 (Stabilin-2)CD44 (CD44 antigen)

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