Drug intelligence / Profile preview

alpha-lipoic acid + L-acetyl carnitine

Development stage
Phase 2
Modality
Small Molecules
Administration
Oral
01

Overview

Alpha-lipoic acid + L-acetyl carnitine is a combination dietary supplement containing two mitochondrial-targeted antioxidants. Alpha-lipoic acid (ALA) acts as a universal antioxidant, effective in both water and fat environments, and helps regenerate other antioxidants such as vitamins C and E. It supports cellular energy production by participating in mitochondrial enzymatic reactions. Acetyl-L-carnitine (ALCAR) is an acetylated form of the amino acid derivative carnitine, which facilitates the transport of fatty acids into mitochondria for beta-oxidation and energy generation. Together, these compounds are believed to reduce oxidative stress, improve mitochondrial function, support healthy aging, promote cardiovascular health by protecting against free radical damage, help maintain blood pressure within normal range, reduce physical and mental fatigue associated with aging, support cognitive function via acetylcholine synthesis (from ALCAR), and may have pain-relieving effects in neuropathies[1][3][4][5]. This combination has been studied for potential benefits in vascular dysfunction (including coronary artery disease), metabolic syndrome-related hypertension[1], neuropathic pain including sciatica[4], age-related cognitive decline[6][7], diabetic neuropathy[8], and general anti-aging applications.

Brand names
Vitacost Alpha Lipoic Acid & Acetyl L-Carnitine HClPiping Rock Acetyl L-Carnitine & Alpha Lipoic AcidSource Naturals Acetyl L-Carnitine & Alpha-Lipoic Acid
Other names
ALA + ALCARacetyl-L-carnitine + alpha-lipoic acid
02

Targets

α-KGDH (Alpha-ketoglutarate dehydrogenase complex)SLC25A20 (Carnitine/acylcarnitine translocase)PPARA (Peroxisome proliferator-activated receptor alpha)PPARG (Peroxisome proliferator-activated receptor gamma)PDH (Pyruvate dehydrogenase complex)FATP (Fatty acid transport protein family)ND1 (Mitochondrial electron transport chain complex I)

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