Drug intelligence / Profile preview

alpha-tocopherol + beta-carotene

Development stage
Discontinued
Lead developer
Finnish Institute for Health and Welfare
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Oral
01

Overview

Alpha-tocopherol (vitamin E) and beta-carotene are fat-soluble antioxidants often combined as dietary supplements. Alpha-tocopherol acts primarily as a chain-breaking antioxidant that protects cell membranes from oxidative damage by scavenging lipid peroxyl radicals. Beta-carotene is a precursor to vitamin A and also functions as an antioxidant, quenching singlet oxygen and neutralizing free radicals. When used together, these compounds exhibit synergistic antioxidant effects in biological membranes, providing greater inhibition of lipid peroxidation than either alone[1]. This combination has been studied for potential roles in cancer prevention and cardiovascular health; however, large clinical trials have shown mixed results regarding efficacy and safety—particularly in smokers or those at high risk for lung cancer[2][3]. The combination is not considered a pharmaceutical drug but rather a dietary supplement.

Other names
vitamin E + beta-caroteneα-tocopherol + β-carotene
02

Targets

^1O2 (Singlet oxygen)RPSA (37/67 kDa laminin receptor)TTPA (Alpha-tocopherol transfer protein)

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