amantadine + oseltamivir

**Amantadine + oseltamivir** is a combination of two approved antiviral drugs, each with distinct mechanisms of action against influenza A virus. **Amantadine** is a small molecule adamantane derivative that inhibits the influenza virus A M2 proton channel, thereby preventing viral uncoating and endosomal escape[2][6]. **Oseltamivir** is a neuraminidase inhibitor that blocks the viral neuraminidase enzyme, impeding viral release and spread from infected cells[4]. The combination has demonstrated synergistic antiviral effects in vitro against multiple subtypes of influenza A (including H1N1, H5N1, and H3N2) at concentrations achievable in human plasma, with no significant cytotoxicity at these doses[1]. This synergy suggests potentially improved antiviral efficacy over monotherapy or double combinations, and may help address resistance issues in influenza treatment[1][3][5].

Brand names

Tamiflu + Symmetrel

Other names

oseltamivir phosphate + amantadine hydrochlorideoseltamivir and amantadine combination