Drug intelligence / Profile preview

american ginseng + salvia miltiorrhiza

Development stage
Unknown
Lead developer
Beijing University of Chinese Medicine East Hospital
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Percutaneous
01

Overview

American ginseng + salvia miltiorrhiza is a traditional Chinese medicine (TCM) combination therapy formulated as an acupoint application patch. Developed by the Dongfang Hospital of Beijing University of Traditional Chinese Medicine, this combination leverages the 'Qi-tonifying' properties of American ginseng (*Panax quinquefolius*) and the 'blood-activating' properties of *Salvia miltiorrhiza* (Danshen). The therapy is primarily investigated as an adjunctive treatment for patients with acute myocardial infarction (AMI) who have undergone percutaneous coronary intervention (PCI). The mechanism involves the synergistic action of ginsenosides and tanshinones to improve left ventricular systolic function, alleviate angina symptoms, and modulate serologic markers of myocardial injury and inflammation. It is administered topically to specific acupoints to enhance recovery and reduce the incidence of major adverse cardiovascular events (MACE).

Other names
Panax quinquefolius + Salvia miltiorrhizaQi-tonifying and blood-activating acupoint patchAmerican ginseng and Danshen combination
02

Targets

P2Y12 (Purinergic P2Y12 receptor)TLR4 (Toll-like receptor 4)

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