Drug intelligence / Profile preview

amino acids + glucose + structured triglycerides

Development stage
Unknown
Lead developer
Fresenius Kabi
Modality
Small Molecules
Administration
Intravenous
01

Overview

The combination of a structural lipid emulsion, amino acids, and glucose refers to a specialized parenteral nutrition (PN) system, most notably marketed under the brand name **StructoKabiven**. This product is typically supplied in a three-chamber bag (3CB) to maintain the stability of the individual components until administration. The defining feature is the 'structural lipid' (Structolipid), which consists of structured triglycerides (STG) where medium-chain fatty acids (MCFA) and long-chain fatty acids (LCFA) are randomly esterified on the same glycerol backbone. This design optimizes metabolic clearance; MCFAs provide a rapid energy source, while LCFAs provide essential fatty acids, and the structured format ensures more efficient hydrolysis by lipoprotein lipase compared to physical mixtures of MCT and LCT. The amino acid component provides nitrogen for protein synthesis, and glucose serves as the primary carbohydrate energy source. It is indicated for adult patients requiring parenteral nutrition in states of malnutrition or postoperative recovery when oral or enteral intake is inadequate or impossible.

Brand names
StructoKabivenStructoKabiven PeripheralStructoKabiven EF
Other names
structural lipid emulsion + amino acid + glucoseSTG-based parenteral nutritionstructured triglycerides + amino acids + glucose
02

Targets

LPL (Lipoprotein lipase)GCK (Glucokinase)Mechanistic target of rapamycin complex 1

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