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amitriptyline + chlordiazepoxide (Roche)
- Development stage
- Unknown
- Lead developer
- Beximco Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Emijoy DS is a fixed-dose combination tablet containing amitriptyline hydrochloride (a tricyclic antidepressant) and chlordiazepoxide (a benzodiazepine anxiolytic). It is manufactured by Beximco Pharmaceuticals and is indicated for the treatment of moderate to severe depression associated with moderate to severe anxiety. Amitriptyline works by inhibiting the reuptake of norepinephrine and serotonin in the central nervous system, thereby enhancing neurotransmission and improving mood. Chlordiazepoxide acts as a positive allosteric modulator of the GABA-A receptor, enhancing GABA-mediated chloride influx to produce sedative and anxiolytic effects.
- Brand names
- Amilin MaxEmijoyEmijoy DSLimbix DSLimbitrolLimbitrol DSReelife DS
- Other names
- amitriptyline hydrochloride + chlordiazepoxideamitriptyline/chlordiazepoxidechlordiazepoxide + amitriptylinechlordiazepoxide/amitriptyline
02
Targets
BZD site (GABA-A receptor benzodiazepine site)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)
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