Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
amitriptyline + chlordiazepoxide + clidinium bromide
- Development stage
- Unknown
- Lead developer
- Fayoum University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Tryptizole + Librax refers to a combination drug regimen evaluated by Fayoum University for the treatment of primary palmar hyperhidrosis. This regimen consists of amitriptyline (the active ingredient in Tryptizole), a tricyclic antidepressant, and Librax, which is a fixed-dose combination of chlordiazepoxide (a benzodiazepine) and clidinium bromide (an anticholinergic). The therapeutic rationale for this combination in hyperhidrosis relies on the potent antimuscarinic properties of both amitriptyline and clidinium bromide, which inhibit the eccrine sweat glands' response to acetylcholine. Additionally, chlordiazepoxide serves to reduce anxiety-induced sympathetic overactivity, a common trigger for palmar sweating. This specific oral combination was compared against stellate ganglion block in clinical research conducted in Egypt.
- Brand names
- TryptizoleLibrax
- Other names
- amitriptyline hydrochloridechlordiazepoxide hydrochlorideclidinium bromide
02
Targets
SERT (Sodium-dependent serotonin transporter)HRH1 (Histamine H1 Receptor)mAChR (Muscarinic acetylcholine receptors)GABRR (GABA-A receptor subunit rho)NET (Norepinephrine Transporter)ADRA1A (α1A)
Beyond the preview
Go deeper on amitriptyline + chlordiazepoxide + clidinium bromide.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on amitriptyline + chlordiazepoxide + clidinium bromide.