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amitriptyline + propranolol
- Development stage
- Unknown
- Lead developer
- Centaur Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Amitriptyline + propranolol** is an oral fixed-dose combination of two small molecules used principally for migraine prophylaxis. Amitriptyline is a tricyclic antidepressant that inhibits neuronal norepinephrine and serotonin reuptake, while propranolol is a nonselective beta-adrenergic receptor blocker. The complementary pharmacology is intended to reduce migraine frequency and may be useful where migraine coexists with tension-type headache features. Marketed Indian products include extended-release tablet presentations such as Health N U's AmNuriteBeta. ([1mg.com](https://www.1mg.com/generics/amitriptyline-propranolol-405636))
- Brand names
- AM-BETAAmnotript-PRAmNuriteBetaEtosis PGaltrip BetaPro ATTriptamin PRTripbetaTriptololTryptojam-Pro
- Other names
- amitriptyline + propranololamitriptyline/propranolol
02
Targets
ADRA1A (α1A)ADRB1 (β1)ADRB2 (β2)HRH1 (Histamine H1 Receptor)mAChR (Muscarinic acetylcholine receptors)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)
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