Drug intelligence / Profile preview

amitriptyline hydrochloride + choline

Development stage
Unknown
Lead developer
Merck
Modality
Small Molecules
Administration
Oral
01

Overview

**Amitriptyline hydrochloride + choline** is an oral combination product marketed as **Sentra PM** or **SentraVil PM**, described as a convenience-packed medical food and drug kit distributed by Targeted Medical Pharma through Physician Therapeutics. The pharmaceutical component is **amitriptyline hydrochloride**, a small-molecule tricyclic antidepressant that inhibits presynaptic reuptake of **serotonin** and **norepinephrine**, while the accompanying choline component is supplied as **choline bitartrate** within a proprietary nutritional formulation that may also include amino acids and related ingredients. The product appears to have been positioned primarily around depression-related use, although amitriptyline itself is also used more broadly for disorders such as major depressive disorder, neuropathic pain, and migraine prevention. Based on the provided context, this is best understood as a combination product that includes an established antidepressant together with a choline-containing medical food formulation rather than a novel molecular entity.

Brand names
Sentra PMSentraVil PM
Other names
amitriptyline hydrochloride + cholineamitriptyline hydrochloride + choline bitartrate
02

Targets

DAT (Dopamine plasma membrane transport protein)HRH1 (Histamine H1 Receptor)mAChR (Muscarinic acetylcholine receptors)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)

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