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amivantamab + carboplatin + pemetrexed
- Development stage
- Unknown
- Lead developer
- Johnson & Johnson
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
Amivantamab + carboplatin + pemetrexed is a combination therapy used for the treatment of non-small cell lung cancer (NSCLC). This regimen combines a bispecific antibody (amivantamab) that targets both EGFR and MET receptors with two chemotherapy agents (carboplatin and pemetrexed). The combination has shown significant improvement in progression-free survival compared to chemotherapy alone in clinical trials.
- Brand names
- Rybrevant + carboplatin + pemetrexed
- Other names
- amivantamab-vmjw + carboplatin + pemetrexed
02
Targets
MET (Mesenchymal-epithelial transition factor receptor)TS (Thymidylate synthase)DNAEGFR T790M (Epidermal growth factor receptor T790M mutant)
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