amlodipine + bisoprolol fumarate + perindopril arginine

Amlodipine + bisoprolol fumarate + perindopril arginine is a **fixed-dose combination** of three antihypertensive agents used as a single-capsule oral therapy for **uncontrolled essential hypertension**. - **Amlodipine** is a dihydropyridine calcium channel blocker that inhibits L-type calcium channels in vascular smooth muscle, leading to vasodilation and decreased peripheral vascular resistance. - **Bisoprolol fumarate** is a selective beta-1 adrenergic receptor antagonist (beta-blocker) that decreases heart rate, cardiac output, and renin release. - **Perindopril arginine** is an angiotensin-converting enzyme (ACE) inhibitor that prevents conversion of angiotensin I to angiotensin II, leading to vasodilation, reduced aldosterone secretion, and lower blood pressure. This single-capsule formulation is developed to improve adherence and simplify therapy for patients requiring three-drug antihypertensive regimens. A phase III randomized study showed the fixed-dose combination is effective and safe in patients with uncontrolled hypertension despite previous mono- or dual-therapy[1].

Brand names

S05166S-05166S 05166

Other names

amlodipine + bisoprolol fumarate + perindopril arginine fixed-dose combination