amlodipine + enalapril maleate

**Amlodipine + enalapril maleate** is a fixed-dose combination of two antihypertensive agents: amlodipine, a dihydropyridine calcium channel blocker, and enalapril maleate, an angiotensin-converting enzyme (ACE) inhibitor. This combination is primarily indicated for the management of hypertension and is sometimes used in patients with angina or some types of chronic heart failure. Amlodipine lowers blood pressure by inhibiting calcium influx into vascular smooth muscle, leading to arterial vasodilation and reduced peripheral resistance. Enalapril lowers blood pressure and provides organ protection by inhibiting ACE, which decreases angiotensin II production and leads to vasodilation, reduced aldosterone secretion, and a decrease in blood volume. The combination has demonstrated superior efficacy in reducing blood pressure compared to either agent alone and may reduce the risk of adverse effects such as peripheral edema relative to amlodipine monotherapy. It is administered orally, typically as a tablet, and is not recommended in children under 6 years of age. It is contraindicated in patients with a history of angioedema related to ACE inhibitors or hypersensitivity to the components[1][2][3][7].

Brand names

AmaceAmlogen-ElAmlovin-EAmtas-EAmzel-ElDilvas-AmEntp-AHytrol-AmKlodip Ace

Other names

amlodipine and enalaprilamlodipine + enalapril