Drug intelligence / Profile preview

amlodipine + indapamide

Development stage
Unknown
Lead developer
Servier
Modality
Small Molecules
Administration
Oral
01

Overview

Amlodipine + indapamide is a fixed-dose combination medication used primarily for the treatment of hypertension (high blood pressure). It combines two active pharmaceutical ingredients with complementary mechanisms of action. Amlodipine is a calcium channel blocker that relaxes blood vessels, making it easier for the heart to pump blood and thereby lowering blood pressure. Indapamide is a thiazide-like diuretic that increases urine production by inhibiting sodium reabsorption in the kidneys, leading to removal of excess water and electrolytes from the body, which also helps reduce blood pressure. This combination provides an effective antihypertensive therapy by targeting different physiological pathways involved in blood pressure regulation[1][4][5][8].

Brand names
NatrixamHypen Max SR
Other names
amlodipine + indapamide
02

Targets

SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)

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