Drug intelligence / Profile preview

amlodipine + irbesartan + hydrochlorothiazide

Development stage
Unknown
Lead developer
Win Medica
Modality
Small Molecules
Administration
Oral
01

Overview

Standard medical therapy-Shanghai Jiao Tong University School of Medicine-hypertension refers to a specific standardized antihypertensive treatment protocol evaluated by the Shanghai Jiao Tong University School of Medicine. This protocol utilizes a sequential, stepped-care approach involving three primary antihypertensive agents: amlodipine (a calcium channel blocker), irbesartan (an angiotensin II receptor blocker), and hydrochlorothiazide (a thiazide diuretic). The regimen begins with amlodipine 5 mg, escalating to amlodipine 5 mg plus irbesartan 150 mg, then to amlodipine 10 mg plus irbesartan 300 mg, and finally adding hydrochlorothiazide 12.5 mg if blood pressure targets are not met. It is designed to provide a simple, effective treatment strategy for uncontrolled hypertension in the Chinese clinical setting.

Other names
Standardized Antihypertensive Treatment Protocolstandard medical therapy-Shanghai Jiao Tong University School of Medicine-hypertension
02

Targets

SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)LTCC (Voltage-gated calcium channel (L-type))AGTR1 (Angiotensin II Type-1 receptor)

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