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amlodipine + metoprolol succinate
- Development stage
- Phase 4
- Lead developer
- Gadin Biotech
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Dinmet-XL AM is a fixed-dose combination drug containing amlodipine, a dihydropyridine calcium channel blocker, and metoprolol succinate, a cardioselective beta-1 adrenergic receptor blocker. Developed and manufactured by Gadin Biotech, it is formulated as an extended-release tablet. Amlodipine acts by inhibiting the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced peripheral resistance. Metoprolol succinate reduces heart rate, cardiac output, and blood pressure by competitively blocking beta-1 receptors. This combination is primarily indicated for the management of hypertension and chronic stable angina, providing synergistic blood pressure control and cardiovascular protection.
- Brand names
- Dinmet-XL AM
- Other names
- Amlodipine and Metoprolol Succinate Extended Release Tablets
02
Targets
CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)ADRB1 (β1)ADRB2 (β2)
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