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amlodipine + perindopril
- Development stage
- Approved
- Lead developer
- Servier
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Amlodipine + perindopril is a fixed-dose combination oral medication used primarily for the treatment of hypertension (high blood pressure). It combines two antihypertensive agents with complementary mechanisms: - Amlodipine is a calcium channel blocker that relaxes and widens blood vessels by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle. - Perindopril is an angiotensin-converting enzyme (ACE) inhibitor that lowers blood pressure by preventing the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced water retention. This combination improves blood pressure control more effectively than monotherapy and may enhance patient adherence due to its single-tablet regimen. It has also demonstrated cardioprotective effects in clinical studies[1][2][5].
- Brand names
- Prestaliapms-PERINDIPRIL-AMLODIPINEAPO-PERINDOPRIL/AMLODIPINE
- Other names
- amlodipine/perindoprilperindopril/amlodipine
02
Targets
ACE (Angiotensin Converting Enzyme)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)LTCC (Voltage-gated calcium channel (L-type))
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