amlodipine besylate + losartan potassium

Amlodipine besylate + losartan potassium is a fixed-dose combination (FDC) antihypertensive medication. It combines amlodipine besylate, a long-acting dihydropyridine calcium channel blocker (CCB), with losartan potassium, an angiotensin II receptor blocker (ARB). Amlodipine works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle cells, resulting in peripheral vasodilation and reduced blood pressure. Losartan selectively blocks the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland, thereby blocking the vasoconstrictor and aldosterone-secreting effects of angiotensin II. This combination is developed by Beijing Hanmi Pharmaceutical for the treatment of primary mild to moderate hypertension, particularly in patients whose blood pressure is not adequately controlled by monotherapy.

Brand names

Amosartan

Other names

amlodipine besylate and losartan potassium