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ammonium chloride + chlorphenamine + guaifenesin + sodium citrate

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

This drug is a **combination medication** containing ammonium chloride, chlorphenamine (also known as chlorpheniramine maleate), guaifenesin, and sodium citrate. It is primarily used in the **symptomatic treatment of cough** associated with the common cold, bronchitis, and other respiratory tract conditions where coughing is accompanied by mucus[1][6]. - **Ammonium chloride** acts as an expectorant by irritating the bronchial mucosa, stimulating the production of respiratory tract fluid, thinning and loosening mucus, and making it easier to cough up[5]. - **Guaifenesin** is an expectorant that increases the output of respiratory tract fluid by reducing the adhesiveness and surface tension of mucus, further facilitating productive cough by making phlegm less viscous[4]. - **Chlorphenamine (chlorpheniramine maleate)** is a first-generation antihistamine that acts as an antagonist at histamine H1 receptors, relieving allergy symptoms such as runny nose, watery eyes, and sneezing[1]. - **Sodium citrate** acts as a mucolytic and expectorant, helping liquefy and decrease the viscosity of mucus, facilitating easier removal from the respiratory tract[6][1]. The combination relieves cough, reduces allergic symptoms, and helps in the removal of mucus in the airways[1][6].

Other names
ammonium chloride + chlorpheniramine maleate + guaifenesin + sodium citrate
02

Targets

HRH1 (Histamine H1 Receptor)

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