ammonium fluoride + calcium fluoride

A two-step dental remineralization agent consisting of **ammonium fluoride solution (AFS, 25,000 ppm F)** applied first, followed by **nano sol calcium fluoride (nano-CaF2, 41,400 ppm F)**, developed by Ivoclar Vivadent AG for treating active buccal white spot lesions (WSLs) in high caries risk adolescents and young adults. It promotes superior caries arrest and remineralization compared to single-step ammonium fluoride varnish (AFV, 7700 ppm F, Fluor Protector S), as shown in a 2025 split-mouth randomized controlled trial where it excelled in quantitative and qualitative assessments of lesion regression[1]. The nano-CaF2 enhances labile fluoride concentration in oral fluid, facilitating apatite formation and reducing dentin permeability[3].

Other names

ammonium fluoride solution + nano sol calcium fluorideAFS + nano-CaF2