Drug intelligence / Profile preview

amoxicillin + amoxicillin + clavulanate + cefadroxil + cefpodoxime + cefalexin + ciprofloxacin + delafloxacin + doxycycline + levofloxacin + linezolid

Development stage
Unknown
Lead developer
GSK
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

This is a combination of **eleven antibiotics**, all commonly used to treat a wide variety of bacterial infections. The agents included span multiple drug classes: - **amoxicillin**: a penicillin antibiotic that inhibits bacterial cell wall synthesis. - **clavulanate**: a beta-lactamase inhibitor that protects beta-lactam antibiotics from enzymatic degradation, enhancing their spectrum. - **cefadroxil**, **cefpodoxime**, **cefalexin**: cephalosporins (first and third generation) that inhibit bacterial cell wall synthesis. - **ciprofloxacin**, **delafloxacin**, **levofloxacin**: fluoroquinolones that inhibit bacterial DNA gyrase and topoisomerase IV. - **doxycycline**: a tetracycline antibiotic that inhibits protein synthesis by binding the 30S ribosomal subunit. - **linezolid**: an oxazolidinone that inhibits the initiation of bacterial protein synthesis by binding to the 50S ribosomal subunit. This combination would confer an extremely broad antibacterial spectrum, including coverage against many Gram-positive and Gram-negative organisms, and both typical and atypical bacteria. Such an extensive combination is not a standard or recognized pharmaceutical product, but a theoretical combination of many antibiotics from various classes.

02

Targets

Class A BL (Class A beta-lactamase)Bacterial RibosomeTopo IV (Bacterial Topoisomerase IV)Bacterial 50S ribosomal subunitDNA gyrasePBP (Penicillin-binding protein family)

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