Drug intelligence / Profile preview

amoxicillin + cefotaxime

Development stage: Preclinical
Lead developer: GSK
Modality: Small Molecules
Administration: Oral, Intravenous, Intramuscular

Overview

A combination antibiotic therapy consisting of amoxicillin (a penicillin-class antibiotic) and cefotaxime (a third-generation cephalosporin). This combination has demonstrated synergistic effects against certain bacterial infections, particularly those caused by extended-spectrum β-lactamase (ESBL)-producing bacteria. The combination works by inhibiting bacterial cell wall synthesis through different but complementary mechanisms.

Targets

PBP (Penicillin-binding protein family)

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