Drug intelligence / Profile preview

amoxicillin + cefuroxime + clarithromycin + clavulanic acid

Development stage
Unknown
Lead developer
GSK
Modality
Small Molecules
Administration
Oral, Intravenous, Intramuscular
01

Overview

This is a combination of four antimicrobial agents: amoxicillin (a penicillin-type antibiotic), cefuroxime (a second-generation cephalosporin), clarithromycin (a macrolide antibiotic), and clavulanic acid (a beta-lactamase inhibitor that protects amoxicillin from degradation by certain bacteria). While individual components or pairs of these medications are commonly used in clinical practice, this specific four-drug combination is not a standard formulation. The individual components have different mechanisms of action against bacteria, with amoxicillin and cefuroxime targeting bacterial cell wall synthesis, clarithromycin inhibiting bacterial protein synthesis, and clavulanic acid protecting beta-lactam antibiotics from degradation by bacterial enzymes.

02

Targets

Bacterial 50S ribosomal subunitPBP (Penicillin-binding protein family)Class A BL (Class A beta-lactamase)

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