amoxicillin + clavulanate (Beaumont Hospital Dublin)

**Amoxicillin + clavulanate** is a fixed-dose antibacterial combination evaluated by Beaumont Hospital Dublin in the completed COMMA trial as non-operative treatment for adults with acute uncomplicated appendicitis. Amoxicillin is an aminopenicillin that inhibits bacterial cell-wall synthesis through penicillin-binding proteins, while clavulanate is a beta-lactamase inhibitor that protects amoxicillin from enzymatic degradation by susceptible beta-lactamase-producing bacteria. The trial protocol used intravenous antibiotic treatment until clinical improvement followed by five days of oral treatment. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02916134))

Brand names

Augmentin

Other names

amoxicillin + clavulanic acidamoxicillin + clavulanate potassiumamoxicillin/clavulanateco-amoxiclavcoamoxiclav