Drug intelligence / Profile preview

amoxycillin + clavulanic acid + ciprofloxacin

Development stage
Unknown
Lead developer
GSK
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

This is a combination of three antibiotics—amoxycillin, clavulanic acid, and ciprofloxacin. Amoxycillin is a penicillin-type beta-lactam antibiotic that inhibits bacterial cell wall synthesis, leading to cell death. Clavulanic acid is a beta-lactamase inhibitor that protects amoxycillin from degradation by beta-lactamase enzymes produced by resistant bacteria, thereby extending its spectrum of activity[3][6]. Ciprofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription in bacteria[10]. This triple combination would provide broad-spectrum antibacterial coverage against both gram-positive and gram-negative organisms—including many resistant strains—and may be considered in severe or mixed infections where multidrug-resistant pathogens are suspected. However, such combinations are not standard therapy and should only be used under strict medical supervision due to the risk of increased side effects and drug interactions.

Other names
Amoxicillin-clavulanate and CiprofloxacinAC-CIF Protocol
02

Targets

NeuraminidaseTopo IV (Bacterial Topoisomerase IV)DNA gyrasePBP (Penicillin-binding protein family)

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