Drug intelligence / Profile preview

amphotericin b deoxycholate + liposomal amphotericin b

Development stage
Unknown
Lead developer
Vestar
Modality
Small Molecules
Administration
Intravenous, Intrathecal
01

Overview

This combination involves two formulations of amphotericin B: amphotericin B deoxycholate, a conventional form, and liposomal amphotericin B, a lipid-associated formulation designed to reduce toxicity. Both are antifungal agents that work by binding to ergosterol in fungal cell membranes, disrupting membrane integrity and leading to cell death. Liposomal amphotericin B is less nephrotoxic and causes fewer infusion-related reactions compared to the conventional form[1][2][5].

02

Targets

Ergosterol

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