ampicillin + amoxicillin

This refers to a specific sequential antibiotic regimen being evaluated by Sheba Medical Center for the management of late preterm premature rupture of membranes (PPROM) between 34.0 and 36.6 weeks of pregnancy. The protocol consists of an initial 48-hour course of intravenous ampicillin (2 grams every 6 hours) followed by a 5-day course of oral amoxicillin (500 mg every 8 hours). Both ampicillin and amoxicillin are small molecule beta-lactam antibiotics in the penicillin class. They function by inhibiting bacterial cell wall synthesis through the binding and inactivation of penicillin-binding proteins (PBPs), which are essential for the cross-linking of the peptidoglycan layer. In the context of PPROM, this regimen serves as the standard-of-care control arm in a Phase 4 clinical trial designed to determine if the addition of a single dose of azithromycin can further improve neonatal outcomes, such as reducing the risk of sepsis and respiratory complications.

Other names

Azithromycin and Ampicillin for Late PPROMstandard antibiotic treatment (ampicillin)