Drug intelligence / Profile preview

ampicillin + cefotaxime + gentamicin

Development stage: Unknown
Lead developer: GSK
Modality: Small Molecules
Administration: Intravenous, Intramuscular

Overview

A combination antibiotic regimen consisting of ampicillin (a beta-lactam antibiotic), cefotaxime (a third-generation cephalosporin), and gentamicin (an aminoglycoside). This triple combination provides broad-spectrum coverage against Gram-positive and Gram-negative bacteria, including extended-spectrum beta-lactamase (ESBL)-producing organisms. It is primarily used for treating serious bacterial infections in neonates and children, particularly in cases of suspected resistant pathogens or Gram-negative meningitis.

Other names: ampicillin and cefotaxime and gentamicinampicillin plus cefotaxime plus gentamicin

Targets

30S A-site (Bacterial ribosomal 30S A-site)PBP (Penicillin-binding protein family)

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