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ampicillin + clavulanic acid
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Drug Delivery Systems, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Ampicillin + clavulanic acid is a combination antibiotic consisting of the penicillin-class beta-lactam antibiotic ampicillin and the beta-lactamase inhibitor clavulanic acid. Ampicillin acts by inhibiting bacterial cell wall synthesis, leading to cell lysis and death in susceptible bacteria. Clavulanic acid inhibits bacterial beta-lactamase enzymes that would otherwise degrade ampicillin, thereby extending its spectrum of activity to include organisms that produce these resistance enzymes. This combination is used to treat a variety of infections caused by susceptible bacteria, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and others[6][7]. The drug can be administered orally or intravenously.
- Brand names
- None specific (most common brands are for amoxicillin + clavulanic acid, not ampicillin + clavulanic acid)
- Other names
- Ampicillin & Clavulanic acid
02
Targets
PBP (Penicillin-binding protein family)PBP3 (Penicillin-binding protein 3)β-lactamase
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