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ampicillin + cloxacillin
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Intramuscular
01
Overview
Ampicillin + cloxacillin is a fixed-dose combination antibiotic used to treat a wide range of bacterial infections, including those of the respiratory tract, ear, nose and throat, urinary tract, skin and soft tissue, gastrointestinal system, bones and joints[1][3][5]. Ampicillin is a broad-spectrum beta-lactam penicillin effective against many gram-positive and gram-negative bacteria. Cloxacillin is a narrow-spectrum penicillin that is resistant to staphylococcal beta-lactamases (penicillinase), making it effective against penicillin-resistant staphylococci. The combination provides synergistic antibacterial activity by covering both susceptible organisms (ampicillin) and beta-lactamase-producing staphylococci (cloxacillin)[2][4][6].
- Brand names
- AmpicloxAmpicloxCare
- Other names
- ampicillin and cloxacillinampicillin/cloxacillin
02
Targets
PBP (Penicillin-binding protein family)
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