Drug intelligence / Profile preview

ampicillin + metronidazole

Development stage: Unknown
Lead developer: Pfizer
Modality: Small Molecules
Administration: Rectal, Intravenous

Overview

Ampicillin + metronidazole is an antibiotic combination used primarily for surgical prophylaxis and treatment of mixed aerobic/anaerobic infections. Ampicillin is a beta-lactam antibiotic effective against many gram-positive and some gram-negative bacteria, while metronidazole is a nitroimidazole antibiotic specifically targeting anaerobic bacteria and certain parasites. This combination provides broad-spectrum coverage and is particularly useful in gynecological surgery prophylaxis and treatment of necrotizing enterocolitis.

Targets

PBP (Penicillin-binding protein family)Neuraminidase

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