ampligen + zidovudine

**Ampligen + zidovudine** is an investigational combination therapy for human immunodeficiency virus (HIV) infection. Ampligen (poly(I):poly(C12U)) is a synthetic double-stranded RNA known as an immune modulator and interferon inducer; it acts as a Toll-like receptor 3 (TLR3) agonist and stimulates antiviral and immune responses. Zidovudine (AZT) is a nucleoside reverse transcriptase inhibitor (NRTI) that blocks HIV’s reverse transcription by incorporating itself into viral DNA and halting elongation. In vitro and early clinical studies indicate **synergistic anti-HIV effects** when ampligen is combined with zidovudine, with increased inhibition of HIV cytopathology and preservation of CD4+ cell counts relative to monotherapy. Development is experimental and was studied in the context of HIV/AIDS primarily in the early 1990s[1][2].

Other names

poly(I):poly(C12U) + AZT