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anastrozole + fulvestrant + gefitinib
- Development stage
- Unknown
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Oral, Intramuscular
01
Overview
A combination therapy consisting of anastrozole (an aromatase inhibitor), fulvestrant (a selective estrogen receptor degrader), and gefitinib (an EGFR tyrosine kinase inhibitor). This triple combination targets both estrogen receptor signaling pathways and EGFR signaling to potentially overcome endocrine resistance in hormone receptor-positive breast cancer.
- Brand names
- Iressa + Arimidex + Faslodex
- Other names
- AFG (anastrozole, fulvestrant, and gefitinib combination)
02
Targets
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