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androsta-4,9(11)-diene-3,17-dione
- Development stage
- Preclinical
- Lead developer
- University of Porto
- Modality
- Small Molecules
- Administration
- Parenteral
01
Overview
Androsta-4,9(11)-diene-3,17-dione is a synthetic steroidal compound investigated for its multi-target anti-cancer properties in estrogen receptor-positive (ER+) breast cancer. It acts as a polypharmacological agent, functioning as an aromatase inhibitor, an androgen receptor (AR) agonist, and a modulator of estrogen receptor (ER) signaling. In preclinical studies using MCF-7aro and AI-resistant LTEDaro cell lines, the compound has demonstrated the ability to arrest cell cycle progression and induce apoptosis, potentially overcoming resistance to standard endocrine therapies like aromatase inhibitors and anti-estrogens.
- Other names
- 4,9-androstadiene-3,17-dioneandrosta-4,9-diene-3,17-dionedelta-9(11)-androstenedione
02
Targets
ER (Estrogen receptor)AR (Adrenergic receptors)CYP19A1 (Aromatase)
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