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Drug intelligence / Profile preview
anti-LAG-3 + pomalidomide + dexamethasone
- Development stage
- Preclinical
- Lead developer
- Bristol Myers Squibb
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Oral
01
Overview
This is a combination therapy consisting of an anti-LAG-3 monoclonal antibody, pomalidomide, and dexamethasone. Anti-LAG-3 antibodies are immune checkpoint inhibitors that block the Lymphocyte Activation Gene-3 (LAG-3) receptor on T cells. By inhibiting LAG-3, these antibodies restore T cell function and enhance the immune system's ability to attack tumor cells[1][2][5]. Pomalidomide is an immunomodulatory small molecule that enhances T-cell and natural killer (NK) cell-mediated immunity and inhibits angiogenesis. Dexamethasone is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties. This combination may be investigated for use in hematologic malignancies such as multiple myeloma or other cancers where immune modulation is beneficial.
- Other names
- anti-LAG-3 + pomalidomide + dexamethasone
02
Targets
CRBN (Cereblon)GR (Glucocorticoid receptor)LAG3 (Lymphocyte activation Gene-3 protein)
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